Hypolipidemic influence of Sargassum subrepandum: mechanism of action.

OBJECTIVES This study aimed to elucidate the role and mode of action of Sargassum subrepandum methanolic extract in management of dyslipidemia in adult female rats. MATERIAL AND METHODS Forty adult female Sprague Dawley rats were assigned into four groups: (1) lean control rats fed on standard diet, (2) dyslipidemia control fed on the atherogenic diet, (3) lean rats orally administered with 100 mg/kg b. wt of Sargassum subrepandum methanolic extract and (4) dyslipidemia rats orally administered with Sargassum subrepandum methanolic extract. Plasma lipid profile, serum MDA, NO, leptin, TNF-alpha and adiponectin levels were demonstrated in the all studied groups. RESULTS The results showed that feeding of rats with athrogenic diet caused significant elevation in plasma cholesterol, triglyceride, LDL, serum MDA, NO, leptin and TNF-alpha levels while, it produced significant decline in plasma HDL and serum adiponectin levels compared with lean control rats. However, treatment of dyslipidemia rats with Sargassum subrepandum methanolic extract induced significant improvement of plasma lipid profile, marked decrease in serum MDA, NO, leptin, TNF-alpha level in concomitant with remarkable increase in serum adiponectin level. CONCLUSIONS These results indicated that Sargassum subrepandum extract plays a vital role in ameliorating dyslipidemia and its complications particularly oxidative stress and implication. This could be attributed to the hypolipidemic effect, antilipidperoxidative activity and antinflammatory property of Sargassum subrepandum methanolic extract.